60x6_edited.jpg

MCELROY LAB

Gastrointestinal Research Lab

RESEARCH PROJECTS

Our long-term research goals are to understand the injury and repair mechanisms of the immature intestine. We are specifically focused on necrotizing enterocolitis (NEC) which is a devastating disorder that predominantly effects preterm infants.

1 from T55 K1 20x_edited.jpg

Determining the impact of antimicrobial peptides on development of intestinal injury

Treatment options for NEC are limited and include bowel rest and antibiotic therapy.  Our lab is investigating the use of antimicrobial peptides to help prevent and treat onset of NEC. 

DSCN0961.JPG

Mechanisms of maternal inflammation-induced bowel injury in neonates

Infants exposed to chorioamnionitis have an increased risk of developing NEC weeks after birth. Our lab is working to understand the impact of fetal exposure to maternal inflammation (FEMI) on the development of the intestine and its host defenses.

Control GFP Klebsiella1.tif

Determining the impact of pre- and probiotics on development of intestinal injury

Multiple studies have shown that probiotic use can decrease the incidence of NEC.  However, it remains unclear which probiotic strains are optimal, and if prebiotic use can further optimize effects. Our lab is working to answer these important gaps in knowledge 

CONTACT US

Office: 2516 Stockton Blvd, Tycon II, Suite 254, Sacramento CA, 95817

Lab: 1204, Research II Bldg, 4625 2nd Ave, Sacramento CA, 95817

(916) 734-3805